CELL MOTILITY Historical Development of Cell Motility
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چکیده
In the first half of the 20 century, it was generally accepted that myosin and actin are proteins specific for muscle, and muscle contractility is a specific interaction of actin, myosin and ATP. It came as a surprise when in 1954 Hoffmann-Berling reported that water-glycerol extracted amnion fibroblasts contract upon addition of ATP. Figures CM1a and 1b show that the elongated fibroblast cells shrink to a small globule after addition of ATP.
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